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Article

Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.

Human molecular genetics - 15 Aug 2007

Spencer Kylee L, Hauser Michael A, Olson Lana M, Schmidt Silke, Scott William K, Gallins Paul, Agarwal Anita, Postel Eric A, Pericak-Vance Margaret A, Haines Jonathan L

Abstract excerpt

Age-related macular degeneration (AMD) is a devastating disorder of the central retina, causing significant visual impairment for 7.5 million elderly Americans. Abnormal regulation of the complement system likely caused by the Y402H polymorphism in the complement factor H gene is a recognized risk factor for AMD, as is the A69S variant in the poorly characterized LOC387715 gene. Recently, polymorphisms in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17576744
DOI: 10.1093/hmg/ddm146

Genes

CFB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.PMID 17576744Read ↗

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