Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Danger-free autoimmune disease in Aire-deficient mice

8 Nov 2007

Abstract excerpt

The danger theory of immune tolerance asserts that environmental factors hold primacy over lymphocyte autoreactivity in initiating autoimmune disease. We sought to test this contention using the Aire-deficient mouse model of the human disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, a multiorgan autoimmune disorder rooted in a lesion in thymic tolerance. Compound screens stimulating a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17991771
DOI: 10.1073/pnas.0709160104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Danger-free autoimmune disease in Aire-deficient micePMID 17991771Read ↗

The development of mouse APECED models provides new insight into the role of AIRE in immune regulation.Semantic proximity Read ↗

Lessons from primary immunodeficiencies: Autoimmune regulator and autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophySemantic proximity Read ↗

Aire deficient mice develop multiple features of APECED phenotype and show altered immune responseSemantic proximity Read ↗

Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype.Semantic proximity Read ↗

The etiopathogenesis of autoimmunity.Semantic proximity Read ↗

AIRE deficiency, from preclinical models to human APECED disease.Semantic proximity Read ↗

Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease.Semantic proximity Read ↗

Where AIRE we now? Where AIRE we going?Semantic proximity Read ↗

Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.Semantic proximity Read ↗

Loss of AIRE-Mediated Immune Tolerance and the Skin.Semantic proximity Read ↗

APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility FactorsSemantic proximity Read ↗

PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.