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Article

Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2018

Napier Ruth J, Lee Ellen J, Vance Emily E, Snow Paige E, Samson Kimberly A, Dawson Clare E, Moran Amy E, Stenzel Peter, Davey Michael P, Sakaguchi Shimon, Rosenzweig Holly L

Abstract excerpt

Arthritis in a genetically susceptible SKG strain of mice models a theoretical paradigm wherein autoimmune arthritis arises because of interplay between preexisting autoreactive T cells and environmental stimuli. SKG mice have a point mutation in ZAP-70 that results in attenuated TCR signaling, altered thymic selection, and spontaneous production of autoreactive T cells that cause arthritis following exposure to...

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Source

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Identifiers

PMID: 30150283
DOI: 10.4049/jimmunol.1700507
PMCID: PMC6143404

Genes

TNF

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