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Article

Metabolic evolution of energy-conserving pathways for succinate production in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2009

Zhang Xueli, Jantama Kaemwich, Moore Jonathan C, Jarboe Laura R, Shanmugam Keelnatham T, Ingram Lonnie O

Abstract excerpt

During metabolic evolution to improve succinate production in Escherichia coli strains, significant changes in cellular metabolism were acquired that increased energy efficiency in two respects. The energy-conserving phosphoenolpyruvate (PEP) carboxykinase (pck), which normally functions in the reverse direction (gluconeogenesis; glucose repressed) during the oxidative metabolism of organic acids, evolved to...

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Identifiers

PMID: 19918073
DOI: 10.1073/pnas.0905396106
PMCID: PMC2777959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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