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Article

T cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008

Barbi Joseph, Brombacher Frank, Satoskar Abhay R

Abstract excerpt

Genetic background influences the outcome of Leishmania major infection. C57BL/6 mice mount a Th1 response and resolve infection. In contrast, BALB/c mice mount a Th2 response and develop chronic lesions. This susceptible phenotype is seen even though BALB/c mice generate IFN-gamma-producing T cells at proportions similar to C57BL/6 mice in their lymph nodes (LN) early after infection. We had previously shown...

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Share to Leishmania major
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CXCR3

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Source

Open in PubMed Open full text

Identifiers

PMID: 18802063
DOI: 10.4049/jimmunol.181.7.4613
PMCID: PMC2562238

Genes

CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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