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Article

IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells

16 Aug 2019

Abstract excerpt

Previous studies infecting global IL-4R-/-, IL-4-/- and IL-13-/- mice on a BALB/c background with the visceralising parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4 and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4R deficient BALB/c mice, we demonstrated that macrophage/neutrophil...

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PMID: 31475014
DOI: 10.3389/fimmu.2019.01957

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