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Article

alphaCaMKII Is essential for cerebellar LTD and motor learning.

Neuron - 21 Sept 2006

Hansel Christian, de Jeu Marcel, Belmeguenai Amor, Houtman Simone H, Buitendijk Gabriëlle H S, Andreev Dmitri, De Zeeuw Chris I, Elgersma Ype

Abstract excerpt

Activation of postsynaptic alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII) by calcium influx is a prerequisite for the induction of long-term potentiation (LTP) at most excitatory synapses in the hippocampus and cortex. Here we show that postsynaptic LTP is unaffected at parallel fiber-Purkinje cell synapses in the cerebellum of alphaCaMKII(-/-) mice. In contrast, a long-term depression (LTD)...

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Identifiers

PMID: 16982427
DOI: 10.1016/j.neuron.2006.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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