Article
PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.
American journal of physiology. Cell physiology - 1 Nov 2008
Seavilleklein Gage, Amer Noha, Evagelidis Alexandra, Chappe Frédéric, Irvine Thomas, Hanrahan John W, Chappe Valérie
Abstract excerpt
Activity of the CFTR channel is regulated by phosphorylation of its regulatory domain (RD). In a previous study, we developed a bicistronic construct called DeltaR-Split CFTR, which encodes the front and back halves of CFTR as separate polypeptides without the RD. These fragments assemble to form a constitutively active CFTR channel. Coexpression of the third fragment corresponding to the missing RD restores...
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