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Article

A cluster of inhibitory residues in the regulatory domain prevents activation of the cystic fibrosis transmembrane conductance regulator.

The Journal of biological chemistry - 1 May 2025

Wu Min, Xiong Yawei, Cao Mengyuan, Zhi Yunqi, Jin Yan, Huang Yizhen, Chen Jeng-Haur

Abstract excerpt

Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl‒ channel requires PKA phosphorylation at the regulatory (R) domain to relieve inhibition of ATP-dependent channel activity. This study aimed to identify the primary inhibitory site that prevents channel activation. CFTR mutants with deletion of residues 760 to 783 (ΔR760-783) elicited constitutive macroscopic and single-channel Cl‒...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40154618
DOI: 10.1016/j.jbc.2025.108460
PMCID: PMC12147182

Genes

CFTR

Variants

Provenance

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