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Article

PKC activators improve the function of biogenesis-deficient CFTR channels.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jul 2026

Ye Shi-Wei, Liu Xi-Juan, Kang Xin-Lei, Shen Li, Cai Shi-Qing

Abstract excerpt

Cystic fibrosis (CF) is a lethal genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most prevalent disease-causing mutation, F508del, results in the production of misfolded CFTR proteins, which are prematurely degraded. Given the complex pathology of CF, a multimodal therapeutic strategy is essential. This underscores the urgent need to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41925277
DOI: 10.1016/j.ymthe.2026.03.033
PMCID: PMC13330007

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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