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Article

Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.

American journal of physiology. Lung cellular and molecular physiology - 1 Oct 2011

Pyle Louise C, Ehrhardt Annette, Mitchell Lisa High, Fan Lijuan, Ren Aixia, Naren Anjaparavanda P, Li Yao, Clancy J P, Bolger Graeme B, Sorscher Eric J, Rowe Steven M

Abstract excerpt

Modulator compounds intended to overcome disease-causing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) show significant promise in clinical testing for cystic fibrosis. However, the mechanism(s) of action underlying these compounds are not fully understood. Activation of CFTR ion transport requires PKA-regulated phosphorylation of the regulatory domain (R-D) and dimerization of the...

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Identifiers

PMID: 21724857
DOI: 10.1152/ajplung.00465.2010
PMCID: PMC3191754

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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