Phosphorylation site independent single R-domain mutations affect CFTR channel activity.

doi:10.1016/s0014-5793(98)01351-9

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Article

Phosphorylation site independent single R-domain mutations affect CFTR channel activity.

FEBS letters - 13 Nov 1998

Wei L, Vankeerberghen A, Cuppens H, Droogmans G, Cassiman J J, Nilius B

Abstract excerpt

We investigated CFTR channel activity of mature R-domain mutants showing single alterations at sites other than the predicted phosphorylation sites. All mutations were found in cystic fibrosis (CF) patients (H620Q, E822K and E826K). The macroscopic CFTR chloride conductance induced by phosphoryla...

Topics

Animals
Anions
COS Cells
Cystic Fibrosis Transmembrane Conductance Regulator
Humans
Ion Transport
Mutation
Oocytes
Phosphorylation
Protein Conformation
Xenopus

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