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Article

Phosphorylation site independent single R-domain mutations affect CFTR channel activity.

FEBS letters - 13 Nov 1998

Wei L, Vankeerberghen A, Cuppens H, Droogmans G, Cassiman J J, Nilius B

Abstract excerpt

We investigated CFTR channel activity of mature R-domain mutants showing single alterations at sites other than the predicted phosphorylation sites. All mutations were found in cystic fibrosis (CF) patients (H620Q, E822K and E826K). The macroscopic CFTR chloride conductance induced by phosphorylation was significantly enhanced in Xenopus oocytes injected with mRNA of H620Q but reduced in the E822K and E826K...

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Source

Identifiers

PMID: 9849891
DOI: 10.1016/s0014-5793(98)01351-9

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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