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Article

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.

Science (New York, N.Y.) - 16 Apr 2004

Tucker Ward C, Weber Thomas, Chapman Edwin R

Abstract excerpt

We investigated the effect of synaptotagmin I on membrane fusion mediated by neuronal SNARE proteins, SNAP-25, syntaxin, and synaptobrevin, which were reconstituted into vesicles. In the presence of Ca2+, the cytoplasmic domain of synaptotagmin I (syt) strongly stimulated membrane fusion when syn...

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Identifiers

PMID: 15044754
DOI: 10.1126/science.1097196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044754-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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