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Article

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion.

Cell - 21 Aug 2009

Hui Enfu, Johnson Colin P, Yao Jun, Dunning F Mark, Chapman Edwin R

Abstract excerpt

Decades ago it was proposed that exocytosis involves invagination of the target membrane, resulting in a highly localized site of contact between the bilayers destined to fuse. The vesicle protein synaptotagmin-I (syt) bends membranes in response to Ca(2+), but whether this drives localized invagination of the target membrane to accelerate fusion has not been determined. Previous studies relied on reconstituted...

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Identifiers

PMID: 19703397
DOI: 10.1016/j.cell.2009.05.049
PMCID: PMC2758036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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