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Article

The p53 G72C and MDM2 T309G single nucleotide polymorphisms in patients with Wegener's granulomatosis.

Clinical and experimental rheumatology - 1 Jan 2000

Assmann G, Wieczorek S, Wibisono D, Roemer K, Arning L, Voswinkel J

Abstract excerpt

OBJECTIVE: Wegener's granulomatosis (WG) is a rare disease with unknown aetiology, but there is evidence for a complex genetic background. The tumor suppressor p53 and its most important negative regulator, MDM2, are positioned in the centre of a pathway that eliminates damaged cells through apoptosis. Furthermore, p53 is one of the most important negative regulators of the pro-inflammatory transcription factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18799058

Genes

MDM2
ACR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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