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Article

Genotypic interaction and gender specificity of common genetic variants in the p53/mdm2 network in Crohn's disease.

Digestion - 1 Jan 2010

Zimmer V, Widmann T, Müller M, Ong M F, Stein J M, Pfreundschuh M, Lammert F, Roemer K, Assmann G

Abstract excerpt

BACKGROUND/AIMS: Defective p53-mediated apoptosis and cell cycle control have been implicated in the immunopathogenesis of Crohn's disease (CD). Since common functional variants of p53 (SNP72 G/C) and its key negative regulator mdm2 (SNP309 T/G) have been reported to affect cellular apoptotic and cell cycle arrest capacities, we assessed the effects of these variants on CD susceptibility and their relationship to...

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PMID: 20110711
DOI: 10.1159/000241413

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NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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