Article
MDM2 T309G has a synergistic effect with P21 ser31arg single nucleotide polymorphisms on the risk of acute myeloid leukemia.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Ebid Gamal T, Sedhom Iman A, El-Gammal Mosaad M, Moneer Manar M
Abstract excerpt
BACKGROUND: The P53 tumor suppressor gene plays a pivotal role in maintaining cellular homeostasis by preventing the propagation of genome mutations. P53 in its transcriptionally active form is capable of activating distinct target genes that contribute to either apoptosis or growth arrest, like P21. However, the MDM2 gene is a major negative regulator of P53. Single nucleotide polymorphisms (SNP) in codon...
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