TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.

doi:10.1016/j.cancergencyto.2009.05.009

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Article

TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.

Cancer genetics and cytogenetics - 1 Nov 2009

Do Thuy N, Ucisik-Akkaya Esma, Davis Charronne F, Morrison Brittany A, Dorak M Tevfik

Abstract excerpt

Genomic and immunologic surveillance mechanisms are crucial in protection from cancer. The tumor suppressor protein p53, encoded by TP53, is a major regulator of genome surveillance. Among the natural sequence variants of TP53, rs1042522 (R72P) modifies the risk for solid tumors. To investigate its relevance in childhood acute lymphoblastic leukemia (ALL) susceptibility, we genotyped 114 cases and 414 newborn...

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PMID: 19837266
DOI: 10.1016/j.cancergencyto.2009.05.009

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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