Article
Single-nucleotide polymorphisms p53 G72C and Mdm2 T309G in patients with psoriasis, psoriatic arthritis, and SAPHO syndrome.
Rheumatology international - 1 Aug 2010
Assmann Gunter, Wagner Annette D, Monika Mueller, Pfoehler Claudia, Pfreundschuh Michael, Tilgen Wolfgang, Roemer Klaus
Abstract excerpt
Psoriasis (Ps), psoriatic arthritis (PsA), and SAPHO syndrome are diseases of unknown etiology that share common clinical features; however, family studies support the hypothesis of a genetic background for each of these diseases. To study the two common single-nucleotide polymorphisms (SNP) in the murine-double-minute-2-(Mdm2) and p53 genes in patients with Ps, PsA, and SAPHO syndrome. Genomic DNA was obtained...
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