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Article

PIK3CA mutations and BRCA1 expression in breast cancer: potential biomarkers for chemoresistance.

Cancer investigation - 1 Dec 2008

Santarpia Mariacarmela, Altavilla Giuseppe, Margeli Mireia, Cirauqui Beatriz, Mesiti Mario, Cavallari Vittorio, Ramirez Jose Luis, Sanchez-Ronco Maria, Santarpia Libero, Taron Miquel, Rosell Rafael

Abstract excerpt

Mutations in PIK3CA and alterations of BRCA1 expression are common in breast cancer and have been correlated with altered sensitivity to taxanes in human cancer cell lines and with outcome of patients. We assessed mutations in the three hotspots of PIK3CA (E542K, E545K and H1047R) and intratumora...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18798071
DOI: 10.1080/07357900802112701

Genes

BRCA1
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18798071-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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