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Article

PIK3CA mutational status in circulating tumor cells can change during disease recurrence or progression in patients with breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2014

Markou Athina, Farkona Sofia, Schiza Christina, Efstathiou Tonia, Kounelis Sophia, Malamos Nikos, Georgoulias Vassilis, Lianidou Evi

Abstract excerpt

PURPOSE: Molecular characterization of circulating tumor cells (CTC) is crucial for the investigation of molecular-targeted therapies while PIK3CA somatic mutations play a crucial role in therapy response. We investigated the presence of PIK3CA mutations in CTC and whether this is associated with clinical outcome. EXPERIMENTAL DESIGN: We developed and validated an ultrasensitive methodology for the detection of...

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Source

Identifiers

PMID: 25398847
DOI: 10.1158/1078-0432.CCR-14-0149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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