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Article

Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo

6 May 2013

Abstract excerpt

Polo-like kinase 1 (PLK1), a member of the serine/threonine protein kinases family, is involved in multiple steps of mitotic progression. It regulates centrosome maturation, mitotic spindle formation, and cytokinesis. While studied extensively in somatic cells, little is known about PLK1 activities in the mammalian preimplantation embryo. We examined the role of PLK1 in the one-cell mouse embryo. Western blotting...

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PMID: 23649868
DOI: 10.1002/mrd.22188

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