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Article

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Nature reviews. Cancer - 1 Nov 2014

Sabharwal Simran S, Schumacker Paul T

Abstract excerpt

Mitochondria cooperate with their host cells by contributing to bioenergetics, metabolism, biosynthesis, and cell death or survival functions. Reactive oxygen species (ROS) generated by mitochondria participate in stress signalling in normal cells but also contribute to the initiation of nuclear or mitochondrial DNA mutations that promote neoplastic transformation. In cancer cells, mitochondrial ROS amplify the...

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Identifiers

PMID: 25342630
DOI: 10.1038/nrc3803
PMCID: PMC4657553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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