Article
ROS in cancer therapy: the bright side of the moon.
Experimental & molecular medicine - 1 Feb 2020
Perillo Bruno, Di Donato Marzia, Pezone Antonio, Di Zazzo Erika, Giovannelli Pia, Galasso Giovanni, Castoria Gabriella, Migliaccio Antimo
Abstract excerpt
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are...
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