Article
Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.
Biochemical and biophysical research communications - 5 Mar 2004
Binnerts Minke E, Wen Xiaohui, Canté-Barrett Kirsten, Bright Jessica, Chen Huang-Tsu, Asundi Vinod, Sattari Peter, Tang Tom, Boyle Bryan, Funk Walter, Rupp Fabio
Abstract excerpt
Drosophila Crossveinless-2 (dCV-2) is required for local activation of Mad phosphorylation in the fruit fly wing and has been postulated to be a positive regulator of BMP-mediated signaling. In contrast, the presence of 5 Chordin-like cysteine-rich domains in the CV-2 protein suggests that CV-2 belongs to a family of well-established inhibitors of BMP function that includes Chordin and Sog [Development 127 (2000)...
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