Article
Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes.
Pharmacogenetics and genomics - 1 Dec 2008
Knouff Christopher W, Lim Noha, Song Kijoung, Yuan Xin, Walker Max C, Townsend Ray, Waeber Gerard, Matthews Paul M, Vollenweider Peter, Waterworth Dawn M, Mooser Vincent
Abstract excerpt
BACKGROUND: A major expectation underlying the search for novel susceptibility genes for common diseases using genome-wide association studies (GWAS) is that these discoveries will lead to new drug targets. This claim has not been verified yet. Here, we tested the hypothesis that common single nucleotide polymorphisms (SNPs) within drug target genes are associated with the corresponding phenotypes, using a...
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