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Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications

25 Mar 2025

Abstract excerpt

Electronic health records (EHRs) coupled with large-scale biobanks offer great promises to unravel the genetic underpinnings of treatment efficacy. However, medication-induced biomarker trajectories stemming from such records remain poorly studied. Here, we extract clinical and medication prescription data from EHRs and conduct GWAS and rare variant burden tests in the UK Biobank (discovery) and the All of Us...

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PMID: 40133288
DOI: 10.1038/s41467-025-58152-3

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