Article
From lipid locus to drug target through human genomics.
Cardiovascular research - 15 Jul 2018
van der Laan Sander W, Harshfield Eric L, Hemerich Daiane, Stacey David, Wood Angela M, Asselbergs Folkert W
Abstract excerpt
In the last decade, over 175 genetic loci have robustly been associated to levels of major circulating blood lipids. Most loci are specific to one or two lipids, whereas some (SUGP1, ZPR1, TRIB1, HERPUD1, and FADS1) are associated to all. While exposing the polygenic architecture of circulating lipids and the underpinnings of dyslipidaemia, these genome-wide association studies (GWAS) have provided further...
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