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Article

Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells.

American journal of physiology. Cell physiology - 1 Nov 2008

Lees Simon J, Childs Tom E, Booth Frank W

Abstract excerpt

Previously, we have demonstrated that forkhead box O3a (FOXO3a) overexpression increased p27(Kip1) promoter activity and protein expression, whereas it decreased proliferation in muscle precursor cells (MPCs). The objectives of the present study were to 1) locate and identify FOXO regulatory elements in the rat p27(Kip1) promoter using deletion analysis of a promoter/reporter construct and 2) determine if...

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Source

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Identifiers

PMID: 18787071
DOI: 10.1152/ajpcell.00349.2008
PMCID: PMC2584982

Genes

FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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