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Article

HIF-1: an age-dependent regulator of lens cell proliferation.

Investigative ophthalmology & visual science - 1 Nov 2008

Shui Ying-Bo, Arbeit Jeffrey M, Johnson Randall S, Beebe David C

Abstract excerpt

PURPOSE: The lens grows throughout life, and lens size is a major risk factor for nuclear and cortical cataracts. A previous study showed that the hypoxic environment around the lens suppressed lens growth in older rats. The present study was conducted to investigate the mechanism responsible for the age-dependent decline in lens cell proliferation. METHODS: Transgenic mice expressing Cre recombinase in the lens...

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Identifiers

PMID: 18586877
DOI: 10.1167/iovs.08-2118
PMCID: PMC2585414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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