Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner.

American journal of physiology. Cell physiology - 1 Aug 2014

Bollinger Lance M, Witczak Carol A, Houmard Joseph A, Brault Jeffrey J

Abstract excerpt

Muscle-specific RING finger-1 (MuRF-1), a ubiquitin ligase and key regulator of proteasome-dependent protein degradation, is highly expressed during skeletal muscle atrophy. The transcription factor forkhead box O3 (FoxO3) induces MuRF-1 expression, but the direct role of other major atrophy-rela...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Forkhead Box Protein O3
Share to Muscle Fibers, Skeletal
Share to Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy

Share to Response Elements

Share to SKP Cullin F-Box Protein Ligases

Share to Smad3 Protein

Share to Tripartite Motif Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24920680
DOI: 10.1152/ajpcell.00391.2013
PMCID: PMC4121583

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24920680-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner.PMID 24920680Read ↗

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle AtrophySemantic proximity Read ↗

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Semantic proximity Read ↗

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.Semantic proximity Read ↗

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3Semantic proximity Read ↗

Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts.Semantic proximity Read ↗

Identification of ubiquitin ligases required for skeletal muscle atrophy.Semantic proximity Read ↗

Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophySemantic proximity Read ↗

A FoxO-Smad synexpression group in human keratinocytes.Semantic proximity Read ↗

Ubiquitin ligases MuRF1 and MAFbx in human skeletal muscle atrophySemantic proximity Read ↗

Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors.Semantic proximity Read ↗

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophySemantic proximity Read ↗

Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.