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Article

Current implications of cyclophilins in human cancers

19 Jul 2010

Abstract excerpt

Cyclophilins (Cyps), the intracellular receptor for immunosuppressant cyclosporine A (CsA), play important cellular roles through activities of peptidyl-prolyl cis-trans isomerase (PPIase) and chaperones. Cyps are structurally conserved and found in both prokaryotic and eukaryotic organisms, including humans which contain 16 Cyp isoforms. Although human Cyps were identified about 25 years ago, their physiological...

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PMID: 20637127
DOI: 10.1186/1756-9966-29-97

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