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Article

ICER expression inhibits leukemia phenotype and controls tumor progression.

Leukemia - 1 Dec 2008

Pigazzi M, Manara E, Baron E, Basso G

Abstract excerpt

The inducible cyclic AMP (cAMP) early repressor (ICER) and cAMP response element-binding protein (CREB) are transcriptional regulators of the cAMP-mediated signaling pathway. CREB has been demonstrated to be upregulated in the majority of childhood leukemias contributing to disease progression, whereas ICER, its endogenous repressor, was found to be downregulated. Our research focus has been the function of...

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Identifiers

PMID: 18784739
DOI: 10.1038/leu.2008.244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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