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Article

CREB engages C/EBPδ to initiate leukemogenesis

27 Apr 2016

Abstract excerpt

cAMP response element binding protein (CREB) is frequently overexpressed in acute myeloid leukemia (AML) and acts as a proto-oncogene; however, it is still debated whether such overactivation alone is able to induce leukemia as its pathogenetic downstream signaling is still unclear. We generated a zebrafish model overexpressing CREB in the myeloid lineage, which showed an aberrant regulation of primitive...

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PMID: 27118402
DOI: 10.1038/leu.2016.98

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