Article
The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias.
Leukemia & lymphoma - 1 Feb 2004
Shankar Deepa B, Sakamoto Kathleen M
Abstract excerpt
Leukemia is a result of accumulating genetic alterations. The collaboration of mutations that offer survival and proliferative signals, together with mutations that result in lack of differentiation, is thought to cause a leukemic phenotype. The cyclic-AMP Response Element Binding Protein (CREB) is a transcription factor that is known to be a downstream component of the GM-CSF and IL-3 signaling pathways. We...
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