Article
PTEN mutations are common in sporadic microsatellite stable colorectal cancer.
Oncogene - 15 Jan 2004
Nassif Najah T, Lobo Glenn P, Wu Xiaojuan, Henderson Christopher J A, Morrison Carl D, Eng Charis, Jalaludin Bin, Segelov Eva
Abstract excerpt
The tumour suppressor gene PTEN, located at chromosome sub-band 10q23.3, encodes a dual-specificity phosphatase that negatively regulates the phosphatidylinositol 3'-kinase (PI3 K)/Akt-dependent cellular survival pathway. PTEN is frequently inactivated in many tumour types including glioblastoma, prostate and endometrial cancers. While initial studies reported that PTEN gene mutations were rare in colorectal...
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