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Article

PTEN mutations are common in sporadic microsatellite stable colorectal cancer.

Oncogene - 15 Jan 2004

Nassif Najah T, Lobo Glenn P, Wu Xiaojuan, Henderson Christopher J A, Morrison Carl D, Eng Charis, Jalaludin Bin, Segelov Eva

Abstract excerpt

The tumour suppressor gene PTEN, located at chromosome sub-band 10q23.3, encodes a dual-specificity phosphatase that negatively regulates the phosphatidylinositol 3'-kinase (PI3 K)/Akt-dependent cellular survival pathway. PTEN is frequently inactivated in many tumour types including glioblastoma,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14724591
DOI: 10.1038/sj.onc.1207059

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14724591-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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PTEN mutations are common in sporadic microsatellite stable colorectal cancer.PMID 14724591Read ↗

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PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.Semantic proximity Read ↗

PTEN gene mutations in colorectal cancers displaying microsatellite instability.Semantic proximity Read ↗

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A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancerSemantic proximity Read ↗

Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumorsSemantic proximity Read ↗

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Semantic proximity Read ↗

Functions and Regulation of the PTEN Gene in Colorectal CancerSemantic proximity Read ↗

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