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Article

PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.

Cancer medicine - 1 Aug 2013

Atreya Chloe E, Sangale Zaina, Xu Nafei, Matli Mary R, Tikishvili Eliso, Welbourn William, Stone Steven, Shokat Kevan M, Warren Robert S

Abstract excerpt

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates the phosphoinositide-3-kinase (PI3K) signaling pathway. In colorectal cancer (CRC), observed frequencies of loss of PTEN expression, concordant expression in primary tumors and metastases, and the association of PTEN status with outcome vary markedly by detection method. We determined the degree to which PTEN expression is...

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Identifiers

PMID: 24156022
DOI: 10.1002/cam4.97
PMCID: PMC3799284

Genes

PTEN
BRAF
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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