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Article

Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.

Nature communications - 25 Mar 2022

Serebriiskii Ilya G, Pavlov Valery, Tricarico Rossella, Andrianov Grigorii, Nicolas Emmanuelle, Parker Mitchell I, Newberg Justin, Frampton Garrett, Meyer Joshua E, Golemis Erica A

Abstract excerpt

Loss of expression or activity of the tumor suppressor PTEN acts similarly to an activating mutation in the oncogene PIK3CA in elevating intracellular levels of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), inducing signaling by AKT and other pro-tumorigenic signaling proteins. Here, we analyze sequence data for 34,129 colorectal cancer (CRC) patients, capturing 3,434 PTEN mutations. We identify specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35338148
DOI: 10.1038/s41467-022-29227-2
PMCID: PMC8956741

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