Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>SIRT3</i> interacts with the <i>daf-16</i> homolog <i>FOXO3a</i> in the Mitochondria, as well as increases <i>FOXO3a</i> Dependent Gene expression

1 Jan 2008

Abstract excerpt

Cellular longevity is a complex process relevant to age-related diseases including but not limited to chronic illness such as diabetes and metabolic syndromes. Two gene families have been shown to play a role in the genetic regulation of longevity; the Sirtuin and FOXO families. It is also established that nuclear Sirtuins interact with and under specific cellular conditions regulate the activity of FOXO gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to FOXO transcription factor regulation
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18781224
DOI: 10.7150/ijbs.4.291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>SIRT3</i> interacts with the <i>daf-16</i> homolog <i>FOXO3a</i> in the Mitochondria, as well as increases <i>FOXO3a</i> Dependent Gene expressionPMID 18781224Read ↗

Sirt3, Mitochondrial ROS, Ageing, and CarcinogenesisSemantic proximity Read ↗

SIRT3: As Simple As It Seems?Semantic proximity Read ↗

A forkhead in the road to longevity: the molecular basis of lifespan becomes clearerSemantic proximity Read ↗

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene ExpressionSemantic proximity Read ↗

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.Semantic proximity Read ↗

Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.Semantic proximity Read ↗

SIRT3: Oncogene and Tumor Suppressor in CancerSemantic proximity Read ↗

SirT3 Regulates the Mitochondrial Unfolded Protein ResponseSemantic proximity Read ↗

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway.Semantic proximity Read ↗

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene TransferSemantic proximity Read ↗

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.Semantic proximity Read ↗

How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family MemberSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.