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Article

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

9 Oct 2012

Abstract excerpt

SIRT3 is a member of the Sir2 family of NAD(+)-dependent protein deacetylases that promotes longevity in many organisms. The processed short form of SIRT3 is a well-established mitochondrial protein whose deacetylase activity regulates various metabolic processes. However, the presence of full-length (FL) SIRT3 in the nucleus and its functional importance remain controversial. Our previous studies demonstrated...

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PMID: 23045395
DOI: 10.1128/mcb.00822-12

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