Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT3: Oncogene and Tumor Suppressor in Cancer

12 Jul 2017

Abstract excerpt

Sirtuin 3 (SIRT3), the major deacetylase in mitochondria, plays a crucial role in modulating oxygen reactive species (ROS) and limiting the oxidative damage in cellular components. SIRT3 targets different enzymes which regulate mitochondrial metabolism and participate in ROS detoxification, such as the complexes of the respiratory chain, the isocitrate dehydrogenase, or the manganese superoxide dismutase. Thus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28704962
DOI: 10.3390/cancers9070090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT3: Oncogene and Tumor Suppressor in CancerPMID 28704962Read ↗

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancerSemantic proximity Read ↗

Sirtuin 3: A Janus face in cancer (Review)Semantic proximity Read ↗

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and DiseaseSemantic proximity Read ↗

SirT3 Regulates the Mitochondrial Unfolded Protein ResponseSemantic proximity Read ↗

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressSemantic proximity Read ↗

Sirtuin-3 (SIRT3) and the Hallmarks of CancerSemantic proximity Read ↗

Function of the SIRT 3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseSemantic proximity Read ↗

SIRT3 and cancer: Tumor promoter or suppressor?Semantic proximity Read ↗

Sirt3, Mitochondrial ROS, Ageing, and CarcinogenesisSemantic proximity Read ↗

SIRT3 regulates mitochondrial biogenesis in aging-related diseasesSemantic proximity Read ↗

The Role of SIRT1 in CancerSemantic proximity Read ↗

The role of SIRT2 in cancer: A novel therapeutic targetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.