Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.

Gene - 15 Apr 2012

D'Aquila Patrizia, Rose Giuseppina, Panno Maria Luisa, Passarino Giuseppe, Bellizzi Dina

Abstract excerpt

Signaling pathways between mitochondrial and nuclear genomes are activated to preserve cellular homeostasis, especially in the event of stress. Using cybrid cell lines, we investigated whether inherited mitochondrial DNA (mtDNA) variants modulate the expression profiles of mammalian sirtuins (SIR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Antioxidants
Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Mammals

Share to Osteosarcoma

Share to Sirtuin 3

Source

Identifiers

PMID: 22326535
DOI: 10.1016/j.gene.2012.01.042

Genes

SIRT3
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22326535-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress.PMID 22326535Read ↗

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and DiseaseSemantic proximity Read ↗

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressSemantic proximity Read ↗

SIRT3 regulates mitochondrial biogenesis in aging-related diseasesSemantic proximity Read ↗

SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.Semantic proximity Read ↗

Sirtuins in mitochondrial stress: Indispensable helpers behind the scenesSemantic proximity Read ↗

SIRT1‐SIRT3 Axis Regulates Cellular Response to Oxidative Stress and EtoposideSemantic proximity Read ↗

SIRT3: Oncogene and Tumor Suppressor in CancerSemantic proximity Read ↗

Sirt3, Mitochondrial ROS, Ageing, and CarcinogenesisSemantic proximity Read ↗

<i>SIRT3</i> interacts with the <i>daf-16</i> homolog <i>FOXO3a</i> in the Mitochondria, as well as increases <i>FOXO3a</i> Dependent Gene expressionSemantic proximity Read ↗

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene ExpressionSemantic proximity Read ↗

Mitochondria and Epigenetics – Crosstalk in Homeostasis and StressSemantic proximity Read ↗

Gene Expression Profiling Reveals Fundamental Sex-Specific Differences in SIRT3-Mediated Redox and Metabolic Signaling in Mouse Embryonic FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.