Genomic Profiling of Lung Adenocarcinoma in Never-Smokers.

doi:10.1200/JCO.21.01691

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Article

Genomic Profiling of Lung Adenocarcinoma in Never-Smokers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2021

Devarakonda Siddhartha, Li Yize, Martins Rodrigues Fernanda, Sankararaman Sumithra, Kadara Humam, Goparaju Chandra, Lanc Irena, Pepin Kymberlie, Waqar Saiama N, Morgensztern Daniel, Ward Jeffrey, Masood Ashiq, Fulton Robert, Fulton Lucinda, Gillette Michael A, Satpathy Shankha, Carr Steven A, Wistuba Ignacio, Pass Harvey, Wilson Richard K, Ding Li, Govindan Ramaswamy

Abstract excerpt

PURPOSE: Approximately 10%-40% of patients with lung cancer report no history of tobacco smoking (never-smokers). We analyzed whole-exome and RNA-sequencing data of 160 tumor and normal lung adenocarcinoma (LUAD) samples from never-smokers to identify clinically actionable alterations and gain insight into the environmental and hereditary risk factors for LUAD among never-smokers. METHODS: We performed...

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PMID: 34591593
DOI: 10.1200/JCO.21.01691
PMCID: PMC8601276

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