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Article

Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.

Cancer research - 14 Jun 2024

Huang Chen-Yang, Jiang Nanhai, Shen Meixin, Lai Gillianne G, Tan Aaron C, Jain Amit, Saw Stephanie P, Ang Mei Kim, Ng Quan Sing, Lim Darren W, Kanesvaran Ravindran, Tan Eng Huat, Tan Wan Ling, Ong Boon-Hean, Chua Kevin L, Anantham Devanand, Takano Angela M, Lim Kiat Hon, Tam Wai Leong, Sim Ngak Leng, Skanderup Anders J, Tan Daniel S, Rozen Steven G

Abstract excerpt

Non-small cell lung cancers (NSCLC) in nonsmokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET and fusions involving ALK and RET. In addition to occurring in nonsmokers, alterations in these "nonsmoking-related oncogenes" (NSRO) also occur in smokers. To better understand the clonal architecture and genomic landscape of NSRO-driven tumors in smokers compared with typical-smoking NSCLCs, we...

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Source

Identifiers

PMID: 38587551
DOI: 10.1158/0008-5472.CAN-23-2551

Genes

ALK
EGFR
ERBB2
MET
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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