Article

Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure

2023-07-06

Abstract excerpt

Non-small cell lung cancers (NSCLCs) in non-smokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET , and fusions involving ALK and RET . We term these “non-smoking-related oncogenes” (NSROs). In addition to occurring in non-smokers, NSRO-driven tumors also occur in smokers, and the clonal architecture and genomic landscape of these tumors remain unknown. We investigated genomic and transc...

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Literature Corpus work: 2c78df90-23a4-5996-b8d0-00f76720540e
DOI: 10.1101/2023.07.04.547310

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