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Article

Characterization of Ser338 phosphorylation for Raf-1 activation.

The Journal of biological chemistry - 14 Nov 2008

Zang Mengwei, Gong Jun, Luo Lingqi, Zhou Jing, Xiang Xiaoqin, Huang Wei, Huang Qiren, Luo Xixi, Olbrot Martin, Peng Yihong, Chen Changyan, Luo Zhijun

Abstract excerpt

Raf kinases are essential for regulating cell proliferation, survival, and tumorigenesis. However, the mechanisms by which Raf is activated are still incompletely understood. Phosphorylation plays a critical role in Raf activation in response to mitogens. The present study characterizes phosphorylation of Ser338, a crucial event for Raf-1 activation. Here we report that mutation of Lys375 to Met diminishes...

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Identifiers

PMID: 18775988
DOI: 10.1074/jbc.M802855200
PMCID: PMC2581588

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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