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Article

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.

Nature cell biology - 1 Sept 2006

von Kriegsheim Alex, Pitt Andrew, Grindlay G Joan, Kolch Walter, Dhillon Amardeep S

Abstract excerpt

The Raf-MEK-ERK pathway couples growth factor, mitogenic and extracellular matrix signals to cell fate decisions such as growth, proliferation, migration, differentiation and survival. Raf-1 is a direct effector of the Ras GTPase and is the initiating kinase in this signalling cascade. Although Raf-1 activation is well studied, little is known about how Raf-1 is inactivated. Here, we used a proteomic approach to...

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Source

Identifiers

PMID: 16892053
DOI: 10.1038/ncb1465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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