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Article

Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation.

Biochemical and biophysical research communications - 9 Dec 1999

Gum R J, Young P R

Abstract excerpt

The mechanism by which different mitogen activated protein kinases (MAPKs) distinguish between different substrates is poorly understood. For example, p38 and SAPK4 are two closely related p38 MAPKs that both phosphorylate ATF2 and MBP. However, p38 phosphorylates MAPKAPK-2 and -3, whereas SAPK4 does not. In this study, we have used mutagenesis to determine the regions of p38 required for substrate selection....

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Source

Identifiers

PMID: 10581204
DOI: 10.1006/bbrc.1999.1787

Genes

ATF2
MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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