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Article

Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation.

Biochemical and biophysical research communications - 9 Dec 1999

Gum R J, Young P R

Abstract excerpt

The mechanism by which different mitogen activated protein kinases (MAPKs) distinguish between different substrates is poorly understood. For example, p38 and SAPK4 are two closely related p38 MAPKs that both phosphorylate ATF2 and MBP. However, p38 phosphorylates MAPKAPK-2 and -3, whereas SAPK4 does not. In this study, we have used mutagenesis to determine the regions of p38 required for substrate selection....

Topics

Activating Transcription Factor 2
Alanine
Amino Acid Sequence
Binding Sites
Cyclic AMP Response Element-Binding Protein
HeLa Cells
Humans
Intracellular Signaling Peptides and Proteins
Mitogen-Activated Protein Kinase 13
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutagenesis

Mutation

Myelin Basic Protein

Phosphorylation

Precipitin Tests

Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 10581204
DOI: 10.1006/bbrc.1999.1787

Genes

ATF2
MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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