Article
Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation.
FEBS letters - 17 Jan 2005
Hekman Mirko, Fischer Andreas, Wennogle Lawrence P, Wang Y Karen, Campbell Sharon L, Rapp Ulf R
Abstract excerpt
The C-Raf kinase is regulated by numerous phosphorylation steps. To quantify the most prominent phosphorylation sites of C-Raf, we performed mass spectrometry analysis of wild-type C-Raf and the constitutively active C-Raf mutant C-Raf-Y340D/Y341D. We confirmed phosphorylation of most of the sites reported in the literature with the exception that we did not detect phosphorylation of threonine 268/269...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.