Article
MEK-1 activates C-Raf through a Ras-independent mechanism.
Biochimica et biophysica acta - 1 May 2013
Leicht Deborah T, Balan Vitaly, Zhu Jun, Kaplun Alexander, Bronisz Agnieszka, Rana Ajay, Tzivion Guri
Abstract excerpt
C-Raf is a member of the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway that plays key roles in diverse physiological processes and is upregulated in many human cancers. C-Raf activation involves binding to Ras, increased phosphorylation and interactions with co-factors. Here, we describe a Ras-independent in vivo pathway for C-Raf activation by its downstream target MEK. Using...
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